Reversing Obesity: Set Point Theory

The set point theory proposes that the human body has a predetermined weight range, or "set point," that it actively defends. This theory suggests that the body regulates its weight through complex physiological mechanisms, including adjusting hunger levels and metabolic rate, to maintain this set point.[1] When an individual's weight deviates from this set point, the body initiates compensatory responses to bring it back to the established range. For example, if someone loses weight, the body might increase hunger and decrease metabolism to promote weight regain. Conversely, if someone gains weight, the body might decrease hunger and increase metabolism to facilitate weight loss.

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The set point theory has significant implications for understanding and treating obesity. It suggests that simply restricting calories or increasing physical activity may not always lead to sustained weight loss, as the body may counteract these efforts by increasing hunger or slowing metabolism.[2] This is because the body perceives the weight loss as a threat and attempts to return to its set point.

The Lancet published research in 2024 that supports the set point theory, highlighting the body's tendency to defend a "set weight" by adjusting hunger and metabolism to resist weight loss.[3] This research underscores the complexity of weight management and the need for approaches that consider the body's natural regulatory mechanisms.


Authoritative Sources

  1. Set Point Theory and Weight Management. [Mayo Clinic]↩
  2. Set Point Theory: What It Is and How It Affects Weight Loss. [Healthline]↩
  3. Obesity and the Set Point: A Review. [The Lancet]↩

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