Here's an analysis of psilocybin microdosing, focusing on its potential effects and current regulatory status as of July 7, 2025.
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The use of psilocybin, particularly in microdoses, has gained attention for its potential therapeutic effects. Research suggests that psilocybin may promote synaptic regeneration through the activation of the 5-HT2A receptor.[1] This mechanism is thought to contribute to its potential benefits in various conditions.
The practice of microdosing psilocybin involves taking very small doses, typically between 0.1 and 0.3 grams, every few days.[1] This approach aims to achieve subtle effects without the full psychedelic experience associated with higher doses. However, it's crucial to understand that microdosing is still considered experimental and is not yet fully understood.
As of July 7, 2025, psilocybin is not FDA-approved for the treatment of any condition, including Alzheimer's disease (AD). [1] Any use of psilocybin, especially microdosing, should be undertaken only under the supervision of a qualified medical professional. This is due to the experimental nature of the treatment and the potential for unknown risks and interactions.
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