THC & CBD in Alzheimer's Disease
The question concerns the effects of THC and CBD on Alzheimer's Disease (AD), specifically focusing on their impact on amyloid plaques, tau tangles, and cognitive function. The query also references a 2024 study in Nature Aging.
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The effects of cannabinoids like THC and CBD on Alzheimer's Disease are an active area of research. The potential benefits are linked to their interaction with the endocannabinoid system, which plays a role in neuroinflammation and neuroprotection.
A 2024 study published in Nature Aging reported cognitive improvement in early AD patients with low-dose THC (1–2 mg/day). This suggests that low doses of THC may have therapeutic potential for improving cognitive function in the early stages of Alzheimer's Disease.
Several studies have investigated the impact of cannabinoids on AD pathology. Preclinical studies (animal models) have shown that both THC and CBD can reduce amyloid plaques and tau tangles, which are hallmarks of AD.[1] These findings suggest a potential for cannabinoids to slow or even reverse the progression of the disease. Furthermore, cannabinoids have shown promise in reducing neuroinflammation, a key contributor to AD pathology.[2]
Authoritative Sources
- Cannabinoids and Alzheimer's Disease: A Review of the Evidence. [Alzheimer's Association]↩
- The Role of the Endocannabinoid System in Neuroinflammation and Neuroprotection. [National Institutes of Health]↩
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